• Vanya Pepelyasheva University “Prof. d-r Asen Zlatarov”, Burgas, Medical college
  • Stefan Harkov University “Prof. d-r Asen Zlatarov”, Burgas, Medical college
Keywords: metabolic syndrome, food supplements, pantotenic acid, nicotinic acid, carnitine


A condition of the human organism, called metabolic Syndrome, increases the risk of diabetes type II, cardiovascular heart disease, stroke. As part of the clinical manifestation of the syndrome are androgenic type obesity, high blood pressure, high atherosclerotic risk, high blood sugar levels and insulin resistance. Which leads to the presence of quantitative biochemical, physiological and anatomical changes: increased blood pressure, increased plasma glucose, increased triglycerides, decreased HDL levels, increased waist circumference. Achieving a complex change in these values implies an improvement in the condition of the body. Favorable change of indicators does not always mean removing the causes of Metabolic Syndrome, but such a change leads to a reduction in the risk of the above-mentioned diseases, which are from the group of socially significant diseases. These values may be affected by changes in the diet and appropriate exercise, which may limit Metabolic Syndrome. This result can be achieved more quickly if combined with food supplements. These supplements can be taken along with medication treatment, but after careful consideration of the combination between them. The food supplements are expected to consist of metabolites in an easily digestible form which may cause some of the following effects: anticoagulant effect, suppression of systolic fatty acids in the liver, suppression of fatty acid esterification in the liver, reduction of LDL level, raising the HDL level. Such metabolites are pantothenic (vitamin B3) and nicotinic acid (vitamin B5). Pantothenic acid is part of the chemical composition of coenzyme A involved in transferase metabolic reactions as an acyl group transporter. More than 70 enzymes in the animal body, including the human body, function with Coenzyme A as a cofactor. Thus, within this cofactor pantothenic acid participates in the catabolism of fatty acids and carbohydrates, and in the anabolism of steroids. Nicotinic acid is part of the chemical composition of nicotinamidadendinucleotide and nicotinamidadendinucleotidephosphate, which are cofactors carrying protons and electrons in the oxidative-reductive metabolic processes. They are involved in the process of cellular respiration and are found in all cell types. Another metabolite related to the metabolic syndrome is carnitine. It is a compound that can form a macro-ganglionic link and transport acyl radicals through the mitochondrial membrane. Thus, he imports into the mitochondria metabolites produced by digesting carbohydrates in a glycolytic exchange and exhausting those produced by the decomposition of fatty acids via the beta-oxidation pathway.


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How to Cite
Pepelyasheva, V., & Harkov, S. (2017). METABOLIC SYNDROME AND NUTRITIONAL SUPPLEMENTS. Knowledge International Journal, 19(4), 1435 - 1437. Retrieved from