IS OXIDATIVE STRESS INJURY RELATED WITH AORTIC CROSS TIME DURATION AFTER OPEN HEART SURGRY?

Authors

  • Kamen Stanev Medical University – Plovdiv, Bulgaria, University hospital “St. Georgi “– Plovdiv – Bulgaria Department of Cardiac surgery
  • Todor Gonovski Medical University – Plovdiv, Bulgaria, University hospital “St. Georgi “– Plovdiv – Bulgaria Department of Cardiac surgery
  • Asen Ivanov Medical University – Plovdiv, Bulgaria, University hospital “St. Georgi “– Plovdiv – Bulgaria Department of Cardiac surgery

Keywords:

oxidative stress, aortic cross time, open heart surgery

Abstract

It is well none that open heart surgery and use of Cardiopulmonary bypass (CPB) is associated with damaging effects in almost all organs in human body. Multiorgan damage is caused by the systemic inflammatory response due to CPB and ischemia – reperfusion over myocardium and other organs. [1-5]. Myocardial injury and dysfunction are caused by the production of radical oxygen species (ROS) [6].  Sources of ROS are mitochondrial cytochrome oxidase, the arachidonic acid cascade, the xanthine oxidoreductase system, and neutrophil granulocytes.

Isoprostanes are products of the arachidonic acid and are produce with oxidation of tissue phospholipids. Increased levels in blood and increased excretion of 8-isoprostane (8-iso-PGF2α) in urine have been found in several pathological situations and levels of 8-isoprostane have been measured previously during coronary reperfusion in patients with on-pump coronary artery bypass graft surgery (CABG). [7–13]

Malondialdehyde (MDA) is a very reactive metabolite with multiple reports indicating its role in carcinogenesis, liver and renal toxicity, diabetes mellitus, cardiovascular and neurovascular diseases, and various effects on nucleic acids [14]. Barrera et al. discussed its effect on osteoporosis, sarcopenia, immunosenescence, and myelodysplastic syndromes [15]. MDA is metabolized by mitochondrial aldehyde dehydrogenase and decarboxylation to acetaldehyde, which is then oxidized to acetate and further to water and CO2 [16,17]. MDA is a metabolite from lipids degradation, which include at least one methylene group. The main MDA precursors are arachidonic, docosahexaenoic, and linolenic acids [21].

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Published

2021-12-15

How to Cite

Stanev, K., Gonovski, T., & Ivanov, A. (2021). IS OXIDATIVE STRESS INJURY RELATED WITH AORTIC CROSS TIME DURATION AFTER OPEN HEART SURGRY?. KNOWLEDGE - International Journal , 49(4), 763–765. Retrieved from https://ikm.mk/ojs/index.php/kij/article/view/4555

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