ASSOCIATION BETWEEN COVID-19, POSTCOVID SYNDROME AND ACUTE VASCULAR OCCLUSIONS

Authors

  • Bogomila Chesmedzhieva UMHAT St.George, Plovdiv, Bulgaria
  • Stefan Stanev UMHAT St.George, Plovdiv, Bulgaria

Keywords:

COVID 19, Postcovid syndrome, Major vascular occlusion

Abstract

In the course of COVID 19 pandemic, there are more and more studies that prove that vascular complications associated with the SARS CoV 2 infection. There are reports for connection between postcovid syndrome and acute thrombosis of the major vessels.
Aim: To explore associations between active SARS CoV 2 infection, postcovid syndrome and the type of vascular occlusions, as well as the time between the thrombotic event occurrence and COVID 19 or postcovid syndrome onset.
Materials and methods: The study is retrospective, conducted in the period July 2020 December 2021. Patients were admitted in Vascular surgery clinic and were splitted in two groups 1) Cases with active COVID 19; 2) Cases with postcovid syndrome. Descriptive, variational and nonparametric analyses were used. P value <0,05 is considered significant.
Results: One hundred twenty one cases were included. The patients were between 29 94 years old, mean age 66,14 years, 80 (66,1%) were male, 41 (33,9%) female. Patients in group 1) were 44 (36,4%), time to thrombotic event varied between 1 and 33 days, mean 7,6 days, median 6 days. Acute arterial occlusions was observed in 38(86,3%), venous thrombosis in 6 (13,6%). In group 2) were included 77 (63,6%) cases, observed time to thrombotic event varied between 1 and 365 days, mean 40,2 days, median 20 days. Acute arterial thrombosis is diagnosed in 41 (53,2%) and venous occlusion in 35(45,4%). In one patient with postcovid syndrome concomitant acute arterial and venous thrombosis was diagnosed.
Discussion: This study demonstrates statistically significant association between active COVID 19 and the onset of thrombotic event patients with active SARS CoV 2 infection are diagnosed with major vessel thrombosis on 7th day (on average), those with postcovid syndrome on the 40th day (p<0,05). Patients with active COVID 19 were significantly more affected by acute arterial thrombosis than those with postcovid syndrome (p<0,05)

Author Biographies

Bogomila Chesmedzhieva, UMHAT St.George, Plovdiv, Bulgaria

Clinic of Vascular Surgery

Stefan Stanev, UMHAT St.George, Plovdiv, Bulgaria

Clinic of Vascular Surgery

References

Behzad, S., Aghaghazvini, L., Radmard, A.R., & Gholamrezanezhad, A. (2020). Extrapulmonary manifestations of COVID-19: radiologic and clinical overview, Clin. Imaging 66 35–41.

Bellosta, R., Luzzani, L., & Natalini, G. (2020). Acute limb ischemia in patients with COVID-19 pneumonia. J Vasc Surg 72:1864.

Borrelli, M.P., Buora, A., & Scrivere, P. (2021). Arterial Thrombotic Sequalae After Covid-19: Mind the Gap. Ann Vasc Surg 75:128.

Björck, M. (2020). European Society for Vascular Surgery (ESVS) Clinical Practice Guidelines on the Management of Acute Limb Ischaemia, European Journal of Vascular and Endovascular Surgery

Gold, D.D., Kurd, R., & Sharon, E. (2021). Don't forget arterial thrombosis in patients with COVID-19: A case series, Thrombosis Update, Volume 5, , 100065, ISSN 2666-5727

Etkin, Y., Conway, A.M., & Silpe, J. (2021). Acute Arterial Thromboembolism in Patients with COVID-19 in the New York City Area. Ann Vasc Surg 70:290.

Fournier, M., Faille, D., & Dossier, A. (2021). Arterial Thrombotic Events in Adult Inpatients With COVID-19. Mayo Clin Proc 96:295.

Gupta, A., Madhavan, M.V., Sehgal, K., Nair, N., & Mahajan, S. (2020). Extrapulmonary manifestations of COVID-19. Nat Med 26: 1017-1032.

Giannis, D., Ziogas, IA., & Gianni, P. (2020). Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-CoV and lessons from the past. J Clin Virol 127:104362.

Griffin, D.O., Jensen, A., & Khan, M. (2020). Pulmonary Embolism and Increased Levels of d-Dimer in Patients with Coronavirus Disease. Emerg Infect Dis 26:1941.

Goudarzi, E., Yousefimoghaddam, F., Ramandi, A. ,& Khaheshi, I. (2021). COVID-19 and Peripheral Artery Thrombosis: A Mini Review, Current Problems in Cardiology, 100992, ISSN 0146-2806

Howard, D.P., Banerjee, A., & Fairhead, J.F. (2015). Population-Based Study of Incidence, Risk Factors, Outcome, and Prognosis of Ischemic Peripheral Arterial Events: Implications for Prevention. Circulation 132:1805.

Ilonzo, N., Judelson, D., & Al-Jundi, W. A. (2021). review of acute limb ischemia in COVID-positive patients. Semin Vasc Surg 34:8.

Kunutsor, S.K., & Laukkanen, J.A. (2020) . Cardiovascular complications in COVID-19: a systematic review and meta-analysis, J. Infect. 81 (2) (e139–e141.

Kunutsor, S.K. , & Laukkanen, J.A. (2020) . Hepatic manifestations and complications of COVID-19: a systematic review and meta-analysis, J. Infect. 81 (3) e72–e74.

Labò, N., Ohnuki, H., & Tosato, G. (2020). Vasculopathy and Coagulopathy Associated with SARS-CoV-2 Infection. Cells. 9:1583.

Surya, S.P., & Santoso, R.M. (2021). A clinical case series of COVID-19-associated acute limb ischemia: real-world situation. Egypt Heart J; 73:59.

Veerasuri, S., Kulkarni, S.R., &Wilson, W.R. (2021). Paravastu SCV. Bilateral Acute Lower Limb Ischemia Secondary to COVID-19. Vasc Endovascular Surg; 55:196.

Downloads

Published

2022-02-18

How to Cite

Chesmedzhieva, B., & Stanev, S. (2022). ASSOCIATION BETWEEN COVID-19, POSTCOVID SYNDROME AND ACUTE VASCULAR OCCLUSIONS. KNOWLEDGE - International Journal , 50(4), 479–482. Retrieved from https://ikm.mk/ojs/index.php/kij/article/view/4954