RELATIONSHIP BETWEEN DRY EYE SYNDROME AND OBSTRUCTIVE SLEEP APNEA
Keywords:
Dry eye syndrome, obstructive sleep apnea, sleep qualityAbstract
Dry eye syndrome is a problem for every ophthalmologist today. Disruption of the mechanism of functioning of the precorneal tear film depends on many factors of influence, both internal and external. The etiology of dry eye syndrome is diverse. The aim of the present study was to investigate the relationship between dry eye syndrome and obstructive sleep apnea. Material and methods: We studied 120 patients who were assessed for the risk of obstructive sleep apnea and dry eye syndrome by conducting a clinical examination and filling out a questionnaire. The results were processed with SPSS v. 20.0, using variation, variance, comparative and correlation analyzes and risk assessment analysis. Results: About 1/3 of the subjects have dry eye syndrome. Dry eye syndrome correlates with male gender, the risk of OSA, post-sleep fatigue, and the risk of sleep fragmentation. Conclusions: Dry eye is associated with poorer results in all quantitative and qualitative aspects of sleep. Current results indicate that patients with OSA are prone to dry eyes. Therefore, clinicians should be aware of the possibility of developing dry eye in patients with OSA.
References
Алексеев, И.Б., & Мельникова, Н.В. (2013). Изменения передней поверхности глаза при первичной открытоугольной глаукоме. Российский меди-цинский журнал. 6(3):4-7
Майчук, Ю.Ф., & Яни, Е.В. (2009). Исследование эффективности применения препарата Офтолик в лечении болезни сухого глаза. KOFT, Заболевания заднего отдела глаза. Т. 10. № 1, 33–35
Муратова, Н.В. (2003). Диагностика и лечение синдрома «сухого глаза» у больных, получающих бета–адреноблокаторы.РМЖ. Клиническая офтальмология. Т. 1, 4–6
Acar, M., Firat, H., Acar, U., & Ardic, S. (2013). Ocular surface assessment in patients with obstructive sleep apnea–hypopnea syndrome. Sleep and Breathing, 17(2), 583-588
Ayaki, M., Kawashima, M., Negishi, K., Kishimoto, T., Mimura, M., & Tsubota, K. (2016). Sleep and mood disorders in women with dry eye disease. Scientific reports, 6(1), 1-8
Ayaki, M., Toda, I., Tachi, N., Negishi, K., & Tsubota, K. (2016). Preliminary report of improved sleep quality in patients with dry eye disease after initiation of topical therapy. Neuropsychiatric disease and treatment, 12, 329
Ayaki, M., Kawashima, M., Negishi, K., Kishimoto, T., Mimura, M., & Tsubota, K. (2016). Sleep and mood disorders in dry eye disease and allied irritating ocular diseases. Scientific reports, 6(1), 1-7
Ayaki, M., Tsubota, K., Kawashima, M., Kishimoto, T., Mimura, M., & Negishi, K. (2018). Sleep disorders are a prevalent and serious comorbidity in dry eye. Investigative ophthalmology & visual science, 59(14), DES143-DES150
Cowie, M. R. (2017). Sleep apnea: state of the art. Trends in cardiovascular medicine, 27(4), 280-289
Holly F.J. (2003) The iatrogenic dry eye and its management //CLES Meeting. – USA, Orlando
Karaca, I., Yagci, A., Palamar, M., Tasbakan, M. S., & Basoglu, O. K. (2019). Ocular surface assessment and morphological alterations in meibomian glands with meibography in obstructive sleep apnea Syndrome. The ocular surface, 17(4), 771-776
Kawashima, M., Uchino, M., Yokoi, N., Uchino, Y., Dogru, M., Komuro, A., ... & Tsubota, K. (2016). The association of sleep quality with dry eye disease: the Osaka study. Clinical ophthalmology (Auckland, NZ), 10, 1015
Latkany R. (2008) Dry eyes: etiology and management. Curr Opin Ophthalmol;19:287–291
Lee, Y. B., Koh, J. W., Hyon, J. Y., Wee, W. R., Kim, J. J., & Shin, Y. J. (2014). Sleep deprivation reduces tear secretion and impairs the tear film. Investigative ophthalmology & visual science, 55(6), 3525-3531
Li, S., Ning, K., Zhou, J., Guo, Y., Zhang, H., Zhu, Y., ... & Li, W. (2018). Sleep deprivation disrupts the lacrimal system and induces dry eye disease. Experimental & molecular medicine, 50(3), e451-e451
Lim, E. W. L., Chee, M. L., Sabanayagam, C., Majithia, S., Tao, Y., Wong, T. Y., ... & Tong, L. (2019). Relationship between sleep and symptoms of tear dysfunction in Singapore Malays and Indians. Investigative ophthalmology & visual science, 60(6), 1889-1897
McDonald, M., Patel, D. A., Keith, M. S., & Snedecor, S. J. (2016). Economic and humanistic burden of dry eye disease in Europe, North America, and Asia: a systematic literature review. The ocular surface, 14(2), 144-167
Morsy, N. E., Amani, B. E., Magda, A. A., Nabil, A. J., Pandi-Perumal, S. R., BaHammam, A. S., ... & Zaki, N. F. (2019). Prevalence and predictors of ocular complications in obstructive sleep apnea patients: a cross-sectional case-control study. The open respiratory medicine journal, 13, 19
Pickering, M. E., Chapurlat, R., Kocher, L., & Peter‐Derex, L. (2016). Sleep disturbances and osteoarthritis. Pain Practice, 16(2), 237-244
Rotatori D. S., Kerr N. C., Raphael B., McLaughlin B. J., Shimizu R., Stern G. A., Schultz G. S. (1994) Elevation of transforming growth factor alpha in cat aqueous humor after corneal endothelial injury //Investigative ophthalmology & visual science. Vol. 35, № 1, 143–149
Stapleton, F., Alves, M., Bunya, V. Y., Jalbert, I., Lekhanont, K., Malet, F., ... & Jones, L. (2017). Tfos dews ii epidemiology report. The ocular surface, 15(3), 334-365
Uchino, M., & Schaumberg, D. A. (2013). Dry eye disease: impact on quality of life and vision. Current ophthalmology reports, 1(2), 51-57
Wu, M., Liu, X., Han, J., Shao, T., & Wang, Y. (2019). Association between sleep quality, mood status, and ocular surface characteristics in patients with dry eye disease. Cornea, 38(3), 311-317
Yu, X., Guo, H., Liu, X., Wang, G., Min, Y., Chen, S. H. S., ... & Yao, K. (2019). Dry eye and sleep quality: a large community-based study in Hangzhou. Sleep, 42(11), zsz160
