CLINICAL LABORATORY EVALUATION OF GESTATIONAL THYROID FUNCTION IN THE FIRST AND SECOND TRIMESTER

Authors

  • Boyan Delev Department of Clinical Laboratory, Faculty of Pharmacy, Medical University Plovdiv, Bulgaria
  • Tanya Deneva Department of Clinical Laboratory, Faculty of Pharmacy, Medical University Plovdiv, Bulgaria
  • Boyan Nonchev Department of Endocrinology, Faculty of Medicine, Medical University of Plovdiv, Bulgaria
  • Antoaneta Argatska Department of Endocrinology, Faculty of Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria
  • Persiyana Nyagolova Department of Endocrinology, Faculty of Medicine, Medical University of Plovdiv, Bulgaria
  • Мaria Miteva Department of Endocrinology, Faculty of Medicine, Medical University of Plovdiv, Bulgaria

Keywords:

pregnancy, thyroid-stimulating hormone (TSH), hypothyroidism, hyperthyroidism

Abstract

To date, much scientific evidence has been accumulated and it is well known that during pregnancy thyroid function undergoes significant changes in the conditions of increased requirements for hormone synthesis and unusual (but physiological) stimulating effects of hCG-human chorionic gonadotropin. These processes are dynamic and are often associated with marked fluctuations in the values of thyroid hormones and TSH-thyroid-stimulating hormone, which increases the risk of misinterpretation of laboratory results and often overdiagnosis of thyroid dysfunction. On the other hand, thyroid dysfunction is associated with significant risks to pregnancy and the fetus, and the correct assessment of the conditions of hypo- or hyperthyroidism is of paramount importance to prevent complications of pregnancy.

The study provides intermediate results of 103 pregnant women from the above groups. All of them had a medical history, a clinical examination and ultrasound examination of the thyroid gland, as well as an assessment of risk factors. Serum concentrations of the following laboratory parameters were measured: thyroid-stimulating hormone (TSH), free thyroxine (FT4), anti-TPO and anti (Tg) antibodies, free triiodothyronone (fT3).

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Published

2021-08-16

How to Cite

Delev, B., Deneva, T., Nonchev, B., Argatska, A., Nyagolova, P., & Miteva М. (2021). CLINICAL LABORATORY EVALUATION OF GESTATIONAL THYROID FUNCTION IN THE FIRST AND SECOND TRIMESTER. KNOWLEDGE - International Journal , 47(4), 569–574. Retrieved from https://ikm.mk/ojs/index.php/kij/article/view/4820