CONCENTRATION OF TOTAL IMMUNOGLOBULIN-E LEVEL IN SERUM OF PATIENTS WITH SARS COV-2 VIRAL INFECTION
Keywords:
SARS CoV-2, allergy, immunoglobulin EAbstract
The COVID-19 epidemic (caused by the SARS-CoV-2 virus) started in December 2019 and was officially declared a pandemic by the World Health Organization (WHO) on March 11, 2020. The currently prevalent SARS-CoV-2 that causes the disease known as COVID-19 is a new virus that has not been previously identified in humans. Most human-to-human transmission occurs through close contact through the transmission of respiratory droplets. This is similar to the flu and other respiratory pathogens. The virus can be transmitted to another person when a person infected with the virus coughs or sneezes. The virus is also transmitted when other people touch these surfaces and then touch their eyes, nose or mouth (mucous membranes).
Common symptoms of infection are: high fever (chills), dry cough, shortness of breath and the most common other symptoms are feeling tired, body aches, dry throat, stuffy nose, runny nose, diarrhea (rare). Some patients may experience severe respiratory symptoms that cause pneumonia. Some patients may need oxygen therapy and when their oxygen needs become high, some patients with COVID-19 need respirator, intensive care and follow-up. Although many of those infected with the virus have only mild symptoms and do not need to be hospitalized, the infection can be fatal, especially for older patients who already have pre-existing medical conditions.
Allergy, on the other hand, is a changed, sensitive reaction of the body's immune system to substances from the environment, which we call allergens. Upon contact with the allergen, the release of mediators from the fat cells is induced, which in turn causes a clinical manifestation of an acute allergic reaction. IgE levels are elevated in: atopic diseases, rhinitis, asthma, dermatitis, parasitic diseases, advanced stage M.Hodgkin and IgE monoclonal myeloma.
Allergy symptoms include a dry throat, stuffy nose, runny nose, shortness of breath, and skin changes.
Some of the symptoms of allergy coincide with the symptoms of COVID infection, so for this purpose it is necessary to define the levels of serum parameters that change during infection with SARS CoV-2, due to the danger of this new disease.
The aim of this study was to show the concentration of Immunoglobulin E in patients with COVID infection because the effect of SARS CoV-2 virus on the level of Immunoglobulin E in patients infected with the virus has not been sufficiently investigated.
Patients with COVID infection in the acute phase, convalescent phase and control group were examined.
The results showed higher IgE levels in patients in the acute phase, and the increase in the recovery phase was associated with patients with more severe inflammatory changes.
In the present study, it was observed that SARS-CoV-2 infection modulates serum IgE levels in both stages of the disease in infected individuals, thereby highlighting an allergic reaction.
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