SUBCLINICAL ATHEROSCLEROSIS AND TYPES OF ATHEROSCLEROTIC PLAQUES IN PATIENTS WITH RHEUMATOID ARTHRITIS

Authors

  • Velichka Popova Medical University Plovdiv, Faculty of Medicine, Bulgaria
  • Mariela Geneva-Popova Medical University Plovdiv, Medical Faculty, Bulgaria
  • Sanislava Popova Medical University Plovdiv, Medical Faculty, Bulgaria

Keywords:

cIMT (carotid intima-media ratio), CV risk (cardiovascular risk) ECS (extracranial vessels), RA (seropositive rheumatoid arthritis), CCA (common carotid artery)

Abstract

Sonographic evaluation of cIMT and the presence of atherosclerotic plaques is an easy and affordable
method to evaluate the different cohorts of patients in our daily practice. In addition to diagnostic screening, it is
also a therapeutic control method that can be used to detect vessel occlusions, to assess the vascular wall,
atherosclerotic changes, to follow their patency, to assess CV risk (cIMT), etc. The general pathogenetic
mechanisms
between joint and vascular inflammation are the unifying factor of these conditions. 69 patients were examined, of
which: 34 patients had seropositive RA (average age: 38.74±7 years), 35 were healthy individuals (control group) –
(average age: 36.93±5.93 years). It was found that 32% of patients with RA (seropositive rheumatoid arthritis) have
subclinical atherosclerosis, which is asymptomatic. In addition, atherosclerotic plaques, mostly of the 1st, 2nd and
3rd types, are present, not occluding the ECS (extracranial vessels).
Keywords: cIMT (carotid intima-media ratio), CV risk (cardiovascular risk), ECS (extracranial vessels), RA
(seropositive rheumatoid arthritis), CA (common carotid artery)

Author Biographies

Velichka Popova, Medical University Plovdiv, Faculty of Medicine, Bulgaria

Department of Rheumatology UMHAL "Kaspella"

Mariela Geneva-Popova, Medical University Plovdiv, Medical Faculty, Bulgaria

Department of Rheumatology,UMHAT "St.George"

Sanislava Popova, Medical University Plovdiv, Medical Faculty, Bulgaria

Department of Rheumatology, UMHAT "St. George"

References

Adawi, M., Firas, S., & Blum, A. (2019). Rheumatoid Arthritis and Atherosclerosis. Isr. Med. Assoc. J. 2019 Jul; 21(7): 460–46

Arts, E.E., Popa, C., den Broeder, A.A., et al. (2015). Performance of four current risk algorithms in predicting cardiovascular events in patients with early rheumatoid arthritis. Ann Rheum Dis 2015;74: 668–74. doi:10.1136/annrheumdis-2013-204024

Bordy, R., Totoson, P., Prati, C., et al. (2018). Microvascular endothelial dysfunction in rheumatoid arthritis. Nat. Rev. Rheumatol. 2018 Jul; 14(7): 404–420

Crowson, C.S., Rollefstad, S., Ikdahl, E., et al. (2018). Impact of risk factors associated with cardiovascular outcomes in patients with rheumatoid arthritis. Ann Rheum Dis 2018;77:48–54

DeMizio, D.J., & Geraldino-Pardilla, L.B. (2020). Autoimmunity and Inflammation Link to Cardiovascular Disease Risk in Rheumatoid Arthritis. Rheumatol Ther. 2020 Mar; 7(1): 19–33

Hannawi, S.M., Hannawi, H., Alokaily, F., et al. (2020). Subclinical atherosclerosis in rheumatoid arthritis patients of the Gulf Cooperated Council. Saudi Med. J. 2020 Sep; 41(9): 1022–1025.

Ikdahl, E., Wibetoe, G., Rollefstad, S., et al. (2019). Guideline recommended treatment to targets of cardiovascular risk is inadequate in patients with inflammatory joint diseases. Int J Cardiol 2019;274:311–8.

Karpouzas, G.A., Ormseth, S.R., Hernandez, E., et al. (2020). Impact of Cumulative Inflammation, Cardiac Risk Factors, and Medication Exposure on Coronary Atherosclerosis Progression in Rheumatoid Arthritis. Arthritis Rheumatol. 2020 Mar; 72(3): 400–408

Koren Krajnc, M., Hojs, R., Holc, I., et al. (2021). Accelerated atherosclerosis in premenopausal women with rheumatoid arthritis - 15-year follow-up. Bosn. J. Basic Med. Sci. 2021 Aug 1; 21(4): 477–483

Lacaille, D., Avina-Zubieta, J.A., Sayre, E.C., et al. (2017). Improvement in 5-year mortality in incident rheumatoid arthritis compared with the general population – closing the mortality gap. Ann Rheum Dis 2017;76:1057–63.

Lawler, P.R., Bhatt, D.L., Godoy, L.C., et al. (2021).Targeting cardiovascular inflammation: next steps in clinical translation. Eur Heart J 2021;42:113–31.

Majka, D.S., Vu, T.T., Pope, R.M., et al. (2017). Association of Rheumatoid Factors With Subclinical and Clinical Atherosclerosis in African American Women: The Multiethnic Study of Atherosclerosis. Arthritis Care Res (Hoboken). 2017 Feb; 69(2): 166–174

Mantel, A., Holmqvist, M., Andersson, D.C., et al. (2017). Association between rheumatoid arthritis and risk of ischemic and nonischemic heart failure. J Am Coll Cardiol 2017;69:1275–85.

Mazarío, R., Jorge, et al. (2022). Cardiovascular risk assessment with carotid ultrasound in rheumatoid arthritis, Medicina Clínica (English Edition), 10.1016/j.medcle.2022.01.021, 159, 10, (470-474), (2022).

Ruscitti, P., Cipriani, P., Liakouli, V., et al. (2019). Subclinical and clinical atherosclerosis in rheumatoid arthritis: results from from the 3-year, multicentre, prospective, observational GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale) study Arthritis Res Ther. 2019; 21: 204.

Downloads

Published

2023-02-15

How to Cite

Popova, V., Geneva-Popova, M., & Popova, S. (2023). SUBCLINICAL ATHEROSCLEROSIS AND TYPES OF ATHEROSCLEROTIC PLAQUES IN PATIENTS WITH RHEUMATOID ARTHRITIS. KNOWLEDGE - International Journal , 56(3), 261–264. Retrieved from https://ikm.mk/ojs/index.php/kij/article/view/5918

Most read articles by the same author(s)

1 2 > >>