PHARMACEUTICAL COMPOUNDING PREPARATIONS: A STUDY ON IBUPROFEN ORAL SUSPENSION
Keywords:
Compounded Ibuprofen Suspension, Galenic practice, Non-sterile preparationsAbstract
This study examines the formulation of pediatric ibuprofen suspension and the evaluation of its stability, in response to the optimized distribution issues of this drug regarding special patient requirements. The study was based on formulating an Ibuprofen oral suspension in a pediatric suitable dosage form (20mg/ml) using two different bases (sucrose and sodium carboxymethylcellulose) that satisfies the organoleptic properties for the paediatric age group. The formulations were evaluated for stability at two different storing conditions: room temperature (20 - 25°c) and refrigerator temperature (2 - 8°C). Each of the formulated suspension stored at different condition was measured for the concentration of Ibuprofen as the active ingredient and physical parameters (the refractive index and pH) on different periods (1, 3, 9, 12 and 15 days prior the formulation) to determine stability.
The content of Ibuprofen in the two formulations stored at two different conditions reflects within limit of percentege of content of Ibuprofen [90-110%]. The storage conditions significantly impact more the physical stability of ibuprofen, as evidenced by changes in the refractive index during the days after the formulation.
The results show that these galenic formulations can ensures stability and comparable quality to approved products. The pharmaceutical practice sector can still rely on compounding practices for special needs of the patients at special situations. Research focusing on the evaluation of the effectiveness and safety of galenic preparations can help improve the quality and confidence of patients and professionals in this field.
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